Adjuvant systemic therapy for early breast cancer
نویسندگان
چکیده
منابع مشابه
Adjuvant systemic therapy for early breast cancer: progress and controversies.
The diagnosis and management of breast cancer have changed considerably over the past 4 decades. The introduction of adjuvant endocrine therapy (ovarian ablation) and adjuvant chemotherapy in the 1960s was a paradigm-changing event, based on improved understanding of the natural history of human breast cancer and the increased realization that micrometastases were in existence in most patients ...
متن کاملAdjuvant systemic therapy for breast cancer.
The first procedure in primary breast cancer is usually the surgical excision of the tumor. However, a medical therapy is necessary in almost all patients to treat the systemic component of the disease. Which medical approach is recommended depends on the biology of the tumor itself. Endocrine-responsive tumors must be treated by an endocrine therapy according to their menopausal status. In HER...
متن کاملAdjuvant Systemic Therapy of Breast Cancer
patients younger than 50 years of 12%, and of endocrine therapy of 12%, as well as for patients older than 50 years with endocrine-responsive disease, with regard to disease-free survival with a follow-up time of 15 years [1]. In HER2/neu-overexpressing breast cancer there is an even larger benefit for patients treated with adjuvant chemotherapy in combination with the antibody trastuzumab (app...
متن کاملSystemic therapy for early breast cancer.
held in Toronto, November 23, 2012. The final recommendations are those for which consensus was reached before or at the meeting. Some of the key evidence was revised after the updated literature search. Evidence reviews for systemic chemotherapy, endocrine therapy, and targeted therapy for her2positive disease are reported in separate articles in this supplement. The full three-part 1-21 evide...
متن کاملMatters of the heart: cardiac toxicity of adjuvant systemic therapy for early-stage breast cancer
Breast cancer remains the most common malignancy in women. Since the late 1980s, significant advances have been made in the treatment of this cancer. Those advances, particularly the ones in the adjuvant setting, have led to declines in the mortality associated with breast cancer. But another result has been treatments that are more complex and that potentially carry more toxicity. One key toxi...
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ژورنال
عنوان ژورنال: Cancer
سال: 1994
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.2820741327